Abstract
Stock centres for our animal models are as important as other scientific resources, such as the primary literature or genome databases. But they need forward planning, international cooperation and secure funding to keep pace with the explosion in functional genomics that relies so heavily on them.
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Acknowledgements
The helpful comments of K. Matthews, S. Brown, N. Jenkins, J. Eppig and M. Hrabe de Angelis are gratefully acknowledged.
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Glossary
- ALLELIC SERIES
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A series of different genotypes, or alleles, at a specific gene locus, that are associated with different phenotypes.
- BALANCER CHROMOSOME
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A chromosome with one or more inverted segments that suppress recombination, ideally over the length of the chromosome. The balancer is usually identified in crosses by a dominant marker and carries at least one recessive lethal mutation. They are used as genetic tools because they allow lethal mutations to be maintained without selection, as the only offspring that will be viable from an intercross will be those that carry the mutation and are heterozygous for the balancer chromosome.
- P-ELEMENTS
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A family of transposable elements that are widely used as the basis of tools for mutating and manipulating the Drosophila genome.
- PENETRANCE
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The frequency with which individuals that carry a given gene will show the manifestations associated with the gene. If penetrance of a disease allele is 100% then all individuals carrying that allele will express the associated disorder.
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Rosenthal, N., Ashburner, M. Taking stock of our models: the function and future of stock centres. Nat Rev Genet 3, 711–717 (2002). https://doi.org/10.1038/nrg891
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DOI: https://doi.org/10.1038/nrg891
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