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A Third signal from Conditioned DCs dictates microbial effector choice

Nature Reviews Immunology volume 16, page 721 (2016)Cite this article

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There are special moments in our lives as scientists when we come across a conceptual synthesis that sheds enormous light on our own research. I enjoyed such an illuminating experience when I discovered the elegant papers of Martien Kapsenberg and Pawel Kalinski on the role of dendritic cells (DCs) in immune polarization. Their work, in common with my own, addressed a core question in microbial immunity regarding how different infectious agents (such as bacteria, protozoa, worms and viruses) trigger distinct CD4+ T helper (TH) cell responses.

exposure to specific microbial products determines the differentiation of DCs to provide a specific type of signal 3

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References

  1. de Jong, E. C. et al. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J. Immunol. 168, 1704–1709 (2002)

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  1. Alan Sher Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892–3202, USA.,

    Alan Sher

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  1. Alan Sher
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Correspondence to Alan Sher.

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Kalinski, P. et al. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20, 561–567 (1999)

Kapsenberg, M. L. Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 3, 984–993 (2003)

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Sher, A. A Third signal from Conditioned DCs dictates microbial effector choice. Nat Rev Immunol 16, 721 (2016). https://doi.org/10.1038/nri.2016.126

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