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Infection

TSLP complements neutrophil killing of bacteria

Nature Reviews Immunology volume 17, page 5 (2017)Cite this article

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TSLP acts on neutrophils to enhance their killing of MRSA

Infections by MRSA typically begin as skin infections but can lead to life-threatening and invasive infections. As TSLP is highly expressed in the skin, the authors investigated whether TSLP could have a role in the immune defence against skin MRSA infections. They found that TSLP treatment resulted in significantly enhanced MRSA killing in in vitro whole-blood killing assays using mouse and human blood. As neutrophils are important for host defence against S. aureus, the authors investigated whether neutrophils could mediate the TSLP-induced killing of bacteria. Indeed, mRNA expression of CRLF2 — which encodes the TSLP receptor cytokine receptor-like factor 2 — increased the response to heat-killed S. aureus by human neutrophils. TSLP had no effect on MRSA killing in neutrophil-depleted blood. Hence, TSLP acts on neutrophils to enhance their killing of MRSA.

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References

  1. West, E. E. et al. A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus. Sci. Immunol. http://dx.doi.org/10.1126/sciimmunol.aaf8471 1, eaaf8471 (2016)

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  1. Elisabeth Kugelberg
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Kugelberg, E. TSLP complements neutrophil killing of bacteria. Nat Rev Immunol 17, 5 (2017). https://doi.org/10.1038/nri.2016.139

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  • DOI: https://doi.org/10.1038/nri.2016.139

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