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Neutrophils

Interfering with intestinal inflammation

Nature Reviews Immunology volume 17, page 594 (2017)Cite this article

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The authors examined the ability of different immune cell subsets that were isolated from mice to respond to IFNλ. Only neutrophils expressed Ifnlr1 (part of the IFNλ receptor) and responded to IFNλ by upregulating an ISG (Rsad2). Furthermore, treating neutrophils with the pro-inflammatory mediators tumour necrosis factor (TNF) or lipopolysaccharide (LPS) upregulated Ifnlr1 expression. Importantly, these results were recapitulated in human neutrophils, as treatment with IFNλ increased the expression of RSAD2 and treatment with LPS upregulated IFNLR1 expression.

Treating human and mouse neutrophils with IFNλ suppressed their ability to produce reactive oxygen species

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References

  1. Broggi, A. et al. IFN-λ suppresses intestinal inflammation by non-translational regulation of neutrophil function. Nat. Immunol. http://dx.doi.org/10.1038/ni.3821 (2017)

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  1. Shimona Starling
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Starling, S. Interfering with intestinal inflammation. Nat Rev Immunol 17, 594 (2017). https://doi.org/10.1038/nri.2017.113

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