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Innate immunity

Platelets on the prowl

Nature Reviews Immunology volume 18, page 3 (2018)Cite this article

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platelets can actively migrate at inflamed sites and are able to collect and bundle bacteria

The authors generated a multicolour platelet reporter mouse to track individual platelets by intravital two-photon microscopy. In a model of needle-induced vascular injury, they observed adherent platelets in the periphery of the injured site that remained motile and seemed autonomous from the thrombus. The platelets were able to migrate against the blood flow and their motility was not affected by migrating leukocytes, suggesting an active process.

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References

  1. Gaertner, F. et al. Migrating platelets are mechno-scavengers that collect and bundle bacteria. Cell 171, 1368–1382 (2017)

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  1. Yvonne Bordon
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Bordon, Y. Platelets on the prowl. Nat Rev Immunol 18, 3 (2018). https://doi.org/10.1038/nri.2017.147

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