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Nature Reviews Immunology volume 7, page 169 (2007)Cite this article

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Any scientist will know that teaming up with other experts in the field can be of huge benefit in achieving the best results. Collaborative behaviour between molecules and cells of the immune system is clearly evident too. In this issue, two Reviews provide excellent examples of such teamwork in the immune system.

On page 179, Giorgio Trinchieri and Alan Sher describe how multiple Toll-like receptors (TLRs) and other pattern-recognition receptors work together to ensure that the most effective immune response is triggered against an invading pathogen. Indeed, stimulation of a single TLR is rarely sufficient to trigger effective host resistance, whereas the collaboration of multiple receptors that activate distinct signalling pathways can be effective at eliminating infection. A greater understanding of such cooperation should provide a basis for the development of better adjuvants and immunotherapeutic regimens.

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From the editors. Nat Rev Immunol 7, 169 (2007). https://doi.org/10.1038/nri2050

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