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Immune regulation

Immune response to tissue stress

Nature Reviews Immunology volume 12, page 1 (2012)Cite this article

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increasing incidence of atopic allergies might reflect ... frequent exposure to environmental toxins that induce sterile tissue stress

Natural killer group 2, member D (NKG2D) is expressed by natural killer (NK) cells, γδ T cells and some CD8+ αβ T cells, and its ligation induces cytotoxic activity and cytokine expression. In human tissues, sterile stress results in the upregulation of the NKG2D ligand MICA (MHC class I polypeptide-related sequence A). In an attempt to characterize the role of highly polymorphic MICA in human lymphoid stress-surveillance responses, Shafi et al. introduced a single copy of different MICA alleles into an identical genomic site in Chinese hamster ovary epithelial cells. Subsequent analysis showed that intragenic variation resulted in different RNA and protein expression levels of each MICA allele.

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ORIGINAL RESEARCH PAPERS

  1. Shafi, S. et al. An NKG2D-mediated human lymphoid stress-surveillance response with high interindividual variation. Sci. Transl. Med. 30 Nov 2011 (doi:10.1126/scitranslmed.3002922)

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  2. Strid, J. et al. The intraepithelial T cell response to NKG2D-ligands links lymphoid stress surveillance to atopy. Science 334, 1293–1297 (2011)Article

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Authors
  1. Maria Papatriantafyllou
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Papatriantafyllou, M. Immune response to tissue stress. Nat Rev Immunol 12, 1 (2012). https://doi.org/10.1038/nri3142

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