Phagocytes come back even stronger

Leavy, Olive

doi:10.1038/nri3163

In Brief
Published: 25 January 2012

Innate immunity

Phagocytes come back even stronger

Olive Leavy

Nature Reviews Immunology volume 12, page 74 (2012)Cite this article

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Lauvau and colleagues have shown that inflammatory monocytes and neutrophils become better pathogen killers during memory responses. The authors found that the enhanced clearance of the intracellular pathogen Listeria monocytogenes following re-infection was associated with increased reactive oxygen species (ROS)-mediated bacterial killing. Indeed, higher numbers of ROS-producing inflammatory monocytes and neutrophils were detected during the memory response, and these inflammatory phagocytes produced higher levels of ROS on a per cell basis, had an increased phagosomal pH and had elevated levels of autophagy compared with cells during the primary response. These enhanced phagocyte functions were decreased in the presence of neutralizing antibodies specific for CC-chemokine ligand 3 (CCL3) or CD8, suggesting that, during a memory response, CCL3 produced by memory CD8⁺ T cells helps to 'license' monocytes and neutrophils to more effectively kill intracellular pathogens.

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ORIGINAL RESEARCH PAPER

Narni-Mancinelli, E. et al. Inflammatory monocytes and neutrophils are licensed to kill during memory responses in vivo. PLoS Pathog. 7, e1002457 (2011)Article
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