TFH cell dynamics in SIV and HIV infection

Papatriantafyllou, Maria

doi:10.1038/nri3317

In Brief
Published: 25 September 2012

Infection

T_FH cell dynamics in SIV and HIV infection

Maria Papatriantafyllou

Nature Reviews Immunology volume 12, page 683 (2012)Cite this article

958 Accesses
Metrics details

Subjects

Access through your institution

Buy or subscribe

HIV targets CD4⁺ T cells, but two studies now report an accumulation of CD4⁺ T follicular helper (T_FH) cells in humans and primates with chronic HIV and SIV infection, respectively. The relative abundance of CXCR5⁺PD1^hi T_FH cells was increased in the lymph nodes of patients with HIV, with a large fraction of T_FH cells being HIV-specific. T_FH cell accumulation correlated with the presence of more germinal centre B cells and plasma cells, and increased IgG1 levels. Similarly, primates with chronic SIV infection had an increased percentage of CCR7^lowPD1^hiICOS^hiCD150^low T_FH cells. T_FH cell accumulation resulted from the differentiation of naive CD4⁺ T cells into T_FH cells, as a result of high IL-6 levels. T_FH cell accumulation in SIV-infected primates also correlated with high IgG levels, but how it may influence antibody maturation remains to be determined.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

Purchase on SpringerLink
Instant access to full article PDF

Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPERS

Lindqvist, M. et al. Expansion of HIV-specific T follicular helper cells in chronic HIV infection. J. Clin. Invest. 122, 3271–3280 (2012)
Article CAS PubMed PubMed Central Google Scholar
Petrovas, C. et al. CD4 T follicular helper cell dynamics during SIV infection. J. Clin. Invest. 122, 3281–3294 (2012)
Article CAS PubMed PubMed Central Google Scholar