The role of PTPN22 in T cell homeostasis

Minton, Kirsty

doi:10.1038/nri3374

In Brief
Published: 14 December 2012

Regulatory T cells

The role of PTPN22 in T cell homeostasis

Kirsty Minton

Nature Reviews Immunology volume 13, page 6 (2013)Cite this article

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Mutations of the gene encoding the cytoplasmic phosphatase PTPN22 confer an increased risk of autoimmunity in humans and mice, and this is associated with increased numbers of B and T cells. However Ptpn22^−/− mice do not spontaneously develop autoimmunity. This study shows that such mice have an increased number of regulatory T (T_Reg) cells with increased immunosuppressive activity, which can prevent autoimmunity caused by Ptpn22^−/− effector T cells in a mouse colitis model. Ptpn22^−/− T_Reg cells secreted higher levels of interleukin-10 (IL-10) than wild-type T_Reg cells and had increased integrin-mediated adhesion downstream of T cell receptor signalling, both of which are crucial for T_Reg cell function. Therefore, PTPN22 regulates both effector and regulatory T cell populations to maintain homeostasis.

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ORIGINAL RESEARCH PAPER

Brownlie, R. J. et al. Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci. Signal. 5, ra87 (2012)
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