A colitis-associated glycome on CD4+ T cells

Minton, Kirsty

doi:10.1038/nri3375

In Brief
Published: 14 December 2012

T cell responses

A colitis-associated glycome on CD4⁺ T cells

Kirsty Minton

Nature Reviews Immunology volume 13, page 6 (2013)Cite this article

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The repertoire of glycan structures on a cell surface (known as the glycome) is determined by glycan-modifying enzymes. Here, the authors show that memory CD4⁺ T cells in the inflamed intestines of mice with colitis have a unique colitis-associated glycome, characterized by the binding of galectin 4, that is associated with downregulation of the enzyme C2GNT (core 2 GlcNAc transferase). CD4⁺ T cells from the inflamed colon of patients with ulcerative colitis also had increased galectin 4 binding and decreased C2GNT expression. CD4⁺ T cells with restored expression of C2GNT were less able to induce colitis, consistent with their lack of the colitis-associated glycome. The colitis-associated glycome was shown to increase the proliferation of memory CD4⁺ T cells through galectin 4-mediated stabilization of lipid rafts, which resulted in sustained PKCθ activation downstream of immune synapses.

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ORIGINAL RESEARCH PAPER

Nishida, A. et al. Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4⁺ T cells. J. Exp. Med. 3 Dec 2012 (doi:10.1084/jem.20112631)

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