SOCS2 and SOCS3 in macrophage polarization

Papatriantafyllou, Maria

doi:10.1038/nri3379

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Published: 21 December 2012

Macrophages

SOCS2 and SOCS3 in macrophage polarization

Maria Papatriantafyllou

Nature Reviews Immunology volume 13, page 7 (2013)Cite this article

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M1 macrophages are pro-inflammatory, whereas M2 macrophages are involved in tissue repair. Here, Spence et al. study the role of suppressor of cytokine signalling 2 (SOCS2) and SOCS3 in macrophage polarization. The phenotypes of Socs2^−/− or Socs3^−/− macrophages were analysed in the absence or presence of polarizing stimuli, and their function was tested in a mouse model of sepsis. Socs2^−/− macrophages were biased towards the M1 subset, whereas Socs3^−/− macrophages had a stable M2 profile. Moreover, compared with controls, Socs2^−/− macrophages had higher levels of phosphorylated STAT1 (signal transducer and activator of transcription 1) following stimulation with interferon-γ, and Socs3^−/− macrophages had higher levels of active STAT6 in response to interleukin-4. As the blockade of these cytokines partially reversed the polarization bias of Socs2^−/− and Socs3^−/− macrophages, SOCS2 and SOCS3 may control macrophage polarization by regulating cytokine–STAT signalling.

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ORIGINAL RESEARCH PAPER

Spence, S. et al. Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization. Immunity 21 Nov 2012 (doi:10.1016/j.immuni.2012.09.013)

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