Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Mucosal immunology

IRF3 maintains gut homeostasis

Nature Reviews Immunology volume 13, page 7 (2013)Cite this article

Subjects

Access through your institution
Buy or subscribe

Here, Negishi et al. investigate the role of interferon-regulatory factor 3 (IRF3) in intestinal homeostasis. Irf3−/− mice showed more severe symptoms of dextran sulphate sodium-induced colitis and impaired disease recovery compared with control mice. Thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33) have homeostatic functions in the gut, and their expression levels were lower in Irf3−/− mice than in wild-type controls, both in the steady state and during colitis. IRF3-dependent expression of TSLP and IL-33 was induced in response to faecal (possibly microbiota-derived) nucleic acids and involved signalling through one of the adaptor proteins MAVS and STING. Finally, IRF3 cooperated with nuclear factor-κB to promote Tslp transcription. Further molecular links between the intestinal microbiota and IRF3-dependent homeostasis remain to be identified.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Negishi, H. et al. Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. Proc. Natl Acad. Sci. USA 3 Dec 2012 (doi:10.1073/pnas.1219482110)Article

Download references

Authors
  1. Maria Papatriantafyllou
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Papatriantafyllou, M. IRF3 maintains gut homeostasis. Nat Rev Immunol 13, 7 (2013). https://doi.org/10.1038/nri3380

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nri3380

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing