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Gene regulation

STATs control subset-specific enhancer activation

Nature Reviews Immunology volume 13, page 7 (2013)Cite this article

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Enhancers are upstream genetic elements that promote transcription, and their activation is marked by several epigenetic changes, including monomethylation of histone H3 lysine 4 and binding of the acetyltransferase p300. Genome-wide analyses of enhancer activation in T helper 1 (TH1) and TH2 cells revealed very distinct profiles. Interestingly, analyses in T helper cells deficient for key signal transducer and activation of transcription (STAT) proteins showed that STATs bind to subset-specific enhancers and control the recruitment of p300 and, thereby, enhancer activation. Overexpression of the master transcriptional regulators T-bet and GATA3 in STAT-deficient TH1 and TH2 cells, respectively, was not sufficient to restore the profile of enhancer activation. Thus, STATs seem to link cytokine signals to transcriptional regulation.

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ORIGINAL RESEARCH PAPER

  1. Vahedi, G. et al. STATs shape the active enhancer landscape of T cell populations. Cell 151, 981–993 (2012)

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  1. Maria Papatriantafyllou
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Papatriantafyllou, M. STATs control subset-specific enhancer activation. Nat Rev Immunol 13, 7 (2013). https://doi.org/10.1038/nri3381

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