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Nature Reviews Neurology volume 6, page 123 (2010)Cite this article

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People with migraine—in particular migraine with aura—have a heightened risk of depression, according to research conducted in The Netherlands. By comparing heritability scores for depression between controls and individuals with migraine, Stam et al. showed that this association could be at least partly attributable to shared genetic factors. Identification of these factors could provide important insights into the etiology of migraine and depression.

Lennox–Gastaut syndrome (LGS) is a severe form of childhood-onset epilepsy that presents a considerable therapeutic challenge for clinicians. Lee et al. assessed the outcome of resective epilepsy surgery in 27 children and adolescents who had LGS and exhibited generalized and multiregional abonormalities on EEG. Over 50% of the patients remained free of seizures on long-term follow-up (mean 33.1 months after surgery). The investigators recommend that resective surgery should be considered in children with LGS, even in the absence of overt lesions on MRI.

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ORIGINAL RESEARCH PAPERS

  1. Stam, A. H. et al. Shared genetic factors in migraine and depression. Neurology 74, 288–294 (2010)

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  2. Lee, Y. J. et al. Resective pediatric epilepsy surgery in Lennox–Gastaut syndrome. Pediatrics 125, e56–e66 (2010)

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  3. Snitz, B. E. et al. Ginkgo biloba for preventing cognitive decline in older adults. JAMA 302, 2663–2670 (2009)

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  4. Lundqvist, C. et al. The severity of dependence score correlates with medication overuse in persons with secondary chronic headaches. The Akershus study of chronic headache. Pain doi: 10.1016/j.pain.2009.12.010

    Article  Google Scholar 

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In brief. Nat Rev Neurol 6, 123 (2010). https://doi.org/10.1038/nrneurol.2010.12

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  • DOI: https://doi.org/10.1038/nrneurol.2010.12

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