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Multiple sclerosis

MicroRNA profiling reveals impaired neurosteroidogenesis

Nature Reviews Neurology volume 7, page 597 (2011)Cite this article

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Three microRNAs that suppress the expression of enzymes involved in neurosteroid synthesis are upregulated in the cerebral white matter of patients with multiple sclerosis (MS), a Canadian study shows. Levels of neurosteroids such as allopregnanolone were reduced in the brains of these patients, and allopregnanolone treatment in a mouse MS model ameliorated some of the neuropathological and neurobehavioral features of the disease. These findings raise the possibility of using neurosteroids as biomarkers or therapeutic agents in MS.

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ORIGINAL RESEARCH PAPER

  1. Noorbakhsh, F. et al. Impaired neurosteroid synthesis in multiple sclerosis. Brain 134, 2703–2721 (2011)

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MicroRNA profiling reveals impaired neurosteroidogenesis. Nat Rev Neurol 7, 597 (2011). https://doi.org/10.1038/nrneurol.2011.170

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