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Motor neuron disease

ALS risk associated with exposure to reproductive hormones

Nature Reviews Neurology volume 8, page 593 (2012)Cite this article

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A population-based study in the Netherlands has found that longer exposure to female reproductive hormones is associated with a reduced risk of amyotrophic lateral sclerosis (ALS). A questionnaire to determine reproductive time span and exposure to endogenous oestrogen was completed by 209 patients with ALS and 672 control individuals. An increased reproductive time span of 1 year decreased the risk of ALS with an odds ratio of 0.95. The results suggest a neuroprotective effect of female reproductive hormones.

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ORIGINAL RESEARCH PAPER

  1. de Jong, S. et al. Endogenous female reproductive hormones and the risk of amyotrophic lateral sclerosis. J. Neurol. doi:10.1007/s00415-012-6665-5

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ALS risk associated with exposure to reproductive hormones. Nat Rev Neurol 8, 593 (2012). https://doi.org/10.1038/nrneurol.2012.208

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