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Stroke

Could the neuroprotective drug NA-1 limit ischaemic brain damage after stroke?

Nature Reviews Neurology volume 8, page 658 (2012)Cite this article

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Despite considerable success in preclinical studies, pharmacological neuroprotective strategies to minimize ischaemic brain damage after stroke have largely failed to translate to the clinic. The results of a new phase II trial published in The Lancet Neurology, however, indicate potential benefits of the neuroprotective drug NA-1 when administered in the immediate aftermath of a stroke.

NA-1 is an inhibitor of the postsynaptic scaffolding protein PSD-95, which is involved in NMDA receptor-mediated excitotoxicity. The drug has previously been shown to have neuroprotective effects in both rodent models and old-world primates.

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References

ORIGINAL RESEARCH PAPER

  1. Hill, M. D. et al. Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 11, 942–950 (2012)

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FURTHER READING

  1. Cook, D. J. et al. Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain. Nature 483, 213–217 (2012)

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Authors
  1. Heather Wood
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Wood, H. Could the neuroprotective drug NA-1 limit ischaemic brain damage after stroke?. Nat Rev Neurol 8, 658 (2012). https://doi.org/10.1038/nrneurol.2012.225

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  • DOI: https://doi.org/10.1038/nrneurol.2012.225

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