Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Genetics

Mutations in potassium channel KCNT1—a novel driver of epilepsy pathogenesis

Nature Reviews Neurology volume 8, page 658 (2012)Cite this article

Subjects

Two studies have identified mutations in a sodium-gated potassium channel gene, KCNT1, as a cause of two forms of early-onset epileptic disorders.

...the spectrum of epilepsies caused by mutations in KCNT1 may be wider than we thought...

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPERS

  1. Heron, S. E. et al. Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy. Nat. Genet. 44, 1188–1190 (2012) doi:10.1038/ng.2440

    Article  CAS  PubMed  Google Scholar 

  2. Barcia, G. et al. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nat. Genet. 44, 1255–1259 (2012)

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Authors
  1. Katie Kingwell
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kingwell, K. Mutations in potassium channel KCNT1—a novel driver of epilepsy pathogenesis. Nat Rev Neurol 8, 658 (2012). https://doi.org/10.1038/nrneurol.2012.229

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneurol.2012.229

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing