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Neurodegenerative disease

Neural stem cell degeneration in PD linked to nuclear defects

Nature Reviews Neurology volume 8, page 660 (2012)Cite this article

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Neural stem cells (NSCs) from patients with Parkinson disease (PD) display ageing-associated nuclear abnormalities that lead to a failure of neurogenesis, according to a recent study in Nature. This study is the first to suggest the involvement of nuclear defects in PD pathogenesis.

“A few years ago we became interested in modelling of ageing-related disease with induced pluripotent stem cells (iPSCs),” says Juan Carlos Izpisua Belmonte, who led the study. “Most studies in PD focus on dopaminergic neurons, but few address the role that NSCs could play, particularly due to the limitations in acquiring these cells.”

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ORIGINAL RESEARCH PAPER

  1. Liu, G.-H. et al. Progressive degeneration of human neural stem cells caused by pathogeneic LRRK2. Nature doi:10.1038/nature11557

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Authors
  1. Katy Malpass
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Malpass, K. Neural stem cell degeneration in PD linked to nuclear defects. Nat Rev Neurol 8, 660 (2012). https://doi.org/10.1038/nrneurol.2012.230

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