Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Multiple sclerosis

Evidence for B-cell exchange across the blood–brain barrier

Nature Reviews Neurology volume 9, page 6 (2013)Cite this article

Subjects

Access through your institution
Buy or subscribe

In patients with multiple sclerosis (MS), a restricted pool of B cells are shared between the cerebrospinal fluid (CSF) and blood, according to a new study. Sequencing of IgG heavy chain genes was used to identify B-cell repertoires, and revealed clonally related B-cell populations on both sides of the blood–brain barrier. Moreover, diversification of different B-cell populations occurred in the blood versus the CSF, indicating that the autoimmune response to CNS antigens is triggered and driven in both the brain and the periphery.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. von Budingen, H.-C. et al. B cell exchange across the blood-brain barrier in multiple sclerosis. J. Clin. Invest. doi:10.1172/JCI63842

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Evidence for B-cell exchange across the blood–brain barrier. Nat Rev Neurol 9, 6 (2013). https://doi.org/10.1038/nrneurol.2012.259

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneurol.2012.259

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing