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Neuroimmunology

Antigen-loaded microparticles—a novel tool to induce T-cell tolerance in autoimmunity?

Nature Reviews Neurology volume 9, page 6 (2013)Cite this article

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In autoimmune disorders such as multiple sclerosis (MS), T cells can be aberrantly activated after recognition of self antigens in the form of peptides. Using a mouse model of MS, Getts et al. show that injection of microparticles loaded with myelin peptides induces long-term T-cell tolerance, preventing disease onset and modifying the disease course. The tolerogenic effect exploited a natural pathway of debris clearance that involves microparticle uptake by macrophages expressing the scavenger receptor MARCO. Regulatory T cells and T-cell anergy were also required for tolerance induction.

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ORIGINAL RESEARCH PAPER

  1. Getts, D. R. et al. Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. Nat. Biotechnol. doi:10.1038/nbt.2434

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Antigen-loaded microparticles—a novel tool to induce T-cell tolerance in autoimmunity?. Nat Rev Neurol 9, 6 (2013). https://doi.org/10.1038/nrneurol.2012.261

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