Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

Parkinson disease

Patients with Parkinson disease show deposition of α-synuclein in cutaneous autonomic nerves

Nature Reviews Neurology volume 9, page 601 (2013)Cite this article

Subjects

Access through your institution
Buy or subscribe

The Parkinson disease (PD)-associated protein α-synuclein accumulates in cutaneous autonomic nerve fibres in patients with this condition, and can be detected in skin biopsy samples, according to a report published in Neurology. The level of α-synuclein deposition in pilomotor and sudomotor nerves was shown to correlate with autonomic dysfunction in PD, and could provide a useful biomarker for this aspect of the disease process.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

ORIGINAL RESEARCH PAPER

  1. Wang, N. et al. α-Synuclein in cutaneous autonomic nerves. Neurology doi:10.1212/WNL.0b013e3182a9f449

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Patients with Parkinson disease show deposition of α-synuclein in cutaneous autonomic nerves. Nat Rev Neurol 9, 601 (2013). https://doi.org/10.1038/nrneurol.2013.220

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrneurol.2013.220

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing