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Neuro-oncology

RNA interference-based nanomedicine provides a new approach for glioblastoma therapy

Nature Reviews Neurology volume 9, page 660 (2013)Cite this article

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Preclinical evaluation of a novel RNA interference technique has demonstrated that nanoparticles carrying small interfering RNAs (siRNAs) can penetrate glioblastoma multiforme (GBM) tumours and modulate the expression of oncogenes and apoptotic genes in mice. Effective targeting of GBM oncogenes by conventional methods is challenging, and the prognosis for GBM has remained poor. Jensen et al. found that systemic delivery of siRNA-conjugated nanoparticles reduced tumour burden without causing adverse effects in a mouse xenograft model of GBM.

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ORIGINAL RESEARCH PAPER

  1. Jensen, S. A. et al. Spherical nucleic acid nanoparticle conjugates as an RNAi-based therapy for glioblastoma. Sci. Transl. Med. doi:10.1126/scitranslmed.3006839

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RNA interference-based nanomedicine provides a new approach for glioblastoma therapy. Nat Rev Neurol 9, 660 (2013). https://doi.org/10.1038/nrneurol.2013.240

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