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Traumatic brain injury

Glymphatic pathway dysfunction after traumatic brain injury might promote tau aggregation

Nature Reviews Neurology volume 11, page 3 (2015)Cite this article

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Traumatic brain injury (TBI) is known to predispose individuals to dementia, but the mechanisms by which TBI promotes long-term neurodegeneration are poorly understood. A new study has shown that TBI impairs the function of the glymphatic system in the brain, thereby promoting aggregation of tau protein, a hallmark of Alzheimer disease. This finding complements previous work showing that the glymphatic pathway facilitates clearance of interstitial amyloid-β in the mouse CNS.

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References

  1. Iliff, J. J. et al. Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury. J. Neurosci. 10.1523/JNEUROSCI.3020-14.2014

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Glymphatic pathway dysfunction after traumatic brain injury might promote tau aggregation. Nat Rev Neurol 11, 3 (2015). https://doi.org/10.1038/nrneurol.2014.245

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