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Multiple sclerosis

Biomarkers and genetic variants reflect disease course in multiple sclerosis

Nature Reviews Neurology volume 12, page 553 (2016)Cite this article

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The pathogenesis of multiple sclerosis (MS) is known to encompass both inflammatory demyelination and neurodegeneration, but the factors that underlie these different aspects of the disease process are poorly understood. Two new studies have identified cerebrospinal fluid (CSF) biomarkers and genetic variants that correlate with the disease course in MS. These findings could open up new avenues of investigation into the pathophysiology of MS.

“There is evidence that glial responses and axonal damage are both present from the early stages of disease, and are important features in the pathogenesis of MS,” says Maria Alba Mañé-Martínez, who led the CSF biomarker study. “The objectives of this research were to investigate glial and neuronal biomarkers in CSF samples from patients with different MS types, and to test whether a correlation among different biomarkers exists.“

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References

  1. Mañé-Martínez, M. A. et al. Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis. J. Neuroimmunol. http://dx.doi.org/10.1016/j.jneuroim.2016.08.004 (2016)

  2. Pan, G. et al. Role of genetic susceptibility variants in predicting clinical course in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry http://dx.doi.org/10.1136/jnnp-2016-313722 (2016)

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  1. Heather Wood
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Wood, H. Biomarkers and genetic variants reflect disease course in multiple sclerosis. Nat Rev Neurol 12, 553 (2016). https://doi.org/10.1038/nrneurol.2016.142

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