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Alzheimer disease

BACE1 inhibition could block CSF tau increase

Nature Reviews Neurology volume 13, page 6 (2017)Cite this article

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Our findings demonstrate that CSF tau levels reflect ... Aβ deposits in the brain

According to a new study in mice that exhibit amyloid pathology similar to that seen in Alzheimer disease (AD), inhibition of beta-site amyloid precursor protein-cleavage enzyme 1 (BACE1) can block amyloid deposition and prevent increases in the level of cerebrospinal fluid (CSF) tau. “Our findings demonstrate that CSF tau levels reflect amyloid-β (Aβ) deposits in the brain,” summarizes Stephan Kaeser, who co-led the study.

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References

  1. Schelle, J. et al. Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. Alzheimers & Dementia http://dx.doi.org/10.1016/j.jalz.2016.09.005 (2016)

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  1. Hemi Malkki
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Malkki, H. BACE1 inhibition could block CSF tau increase. Nat Rev Neurol 13, 6 (2017). https://doi.org/10.1038/nrneurol.2016.170

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