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Parkinson disease

Dopamine receptor variants improve response to rasagiline in PD

Nature Reviews Neurology volume 12, page 372 (2016)Cite this article

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Two single nucleotide polymorphisms (SNPs) in DRD2, the gene that encodes the dopamine D2 receptor, are associated with improved responses to rasagiline in early Parkinson disease (PD), according to new research. The findings could help to predict treatment responses and tailor therapy to individuals.

Rasagiline is a monoamine oxidase B inhibitor that is used for symptomatic treatment of PD. As with many PD therapies, the response to rasagiline is typically good in early PD, and diminishes with disease progression, but not all patients respond in the same way.

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References

  1. Masellis, M. et al. Dopamine D2 receptor gene variants and response to rasagiline in early Parkinson's disease: a pharmacogenetic study. Brain http://dx.doi.org/10.1093/brain/aww109 (2016)

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  1. Ian Fyfe
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Fyfe, I. Dopamine receptor variants improve response to rasagiline in PD. Nat Rev Neurol 12, 372 (2016). https://doi.org/10.1038/nrneurol.2016.83

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