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Multiple sclerosis

Immune reconstitution effective for MS

Nature Reviews Neurology volume 12, page 429 (2016)Cite this article

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Complete immunoablation followed by autologous haematopoietic stem cell transplantation (aHSCT) stops progression of multiple sclerosis (MS), a recently published trial shows. The treatment had greater efficacy than any other available therapeutic approach to MS, and could offer a new way of tackling aggressive disease in some patients.

Immune system suppression and aHSCT for MS has previously produced promising results in short follow-up periods, but no treatment has prevented the disease from eventually re-emerging in some patients. In the new study, Harold Atkins and colleagues tested a more aggressive approach in 24 patients with aggressive disease and poor responses to treatment.

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References

  1. Atkins, H. L. et al. Immunoablation and autologous haematopoietic stem cell transplantation. Lancet http://dx.doi.org/10.1016/S0140-6736(16)30169-6 (2016)

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  1. Ian Fyfe
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Fyfe, I. Immune reconstitution effective for MS. Nat Rev Neurol 12, 429 (2016). https://doi.org/10.1038/nrneurol.2016.96

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