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Chicken collagen for RA

Nature Reviews Rheumatology volume 6, page 65 (2010)Cite this article

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Researchers from Annhui Medical University in Hefei, China have shown that an orally administered form of type II collagen (CII) extracted from chicken breast cartilage is considerably safer, but less effective, than low-dose methotrexate for the treatment of rheumatoid arthritis (RA).

Administration of chicken CII is thought to induce peripheral immunological tolerance to CII, the main constituent of human cartilage and a potential autoantigen involved in the pathogenesis and/or progression of RA. The precise mechanisms underlying the induction of immunological tolerance are unknown, but are thought to involve clonal deletion, suppression of type 1 T helper cells and induction of regulatory T cells.

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ORIGINAL RESEARCH PAPERS

  1. Wei, W. et al. A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res. Ther. 11, R180 (2009)

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  1. Negin Nassabeh
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Nassabeh, N. Chicken collagen for RA. Nat Rev Rheumatol 6, 65 (2010). https://doi.org/10.1038/nrrheum.2010.1

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  • DOI: https://doi.org/10.1038/nrrheum.2010.1

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