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Osteoarthritis

The influence of obesity on OA—does size matter or is metabolic dysfunction more important?

Nature Reviews Rheumatology volume 8, page 61 (2012)Cite this article

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Obesity is on the increase worldwide, and is associated not only with type 2 diabetes mellitus, but also osteoarthritis (OA). New data published in Arthritis Research & Therapy support the theory that the metabolic dysfunction that occurs with obesity can increase OA progression and might even have a greater influence on the disease than body weight.

Robert Mooney and colleagues at the University of Rochester, USA, put C57BL/6 mice on a high-fat diet either 8 weeks before or directly after surgical induction of meniscal–ligamentous knee injury. OA progression was monitored during the 4 months after surgery.

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References

Original research paper

  1. Mooney, R. A. et al. High fat diet accelerates progression of osteoarthritis following meniscal/ligamentous injury. Arthritis Res. Ther. 13, R198 (2011)

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Further reading

  1. Aspden, R. M. Obesity punches above its weight in osteoarthritis. Nat. Rev. Rheumatol. 7, 65–68 (2011)

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  1. David Killock
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Killock, D. The influence of obesity on OA—does size matter or is metabolic dysfunction more important?. Nat Rev Rheumatol 8, 61 (2012). https://doi.org/10.1038/nrrheum.2011.221

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