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Osteoarthritis

Local antagonism of endothelin-1 and bradykinin receptors improves OA pain and joint morphology in rats

Nature Reviews Rheumatology volume 7, page 375 (2011)Cite this article

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specific receptor antagonism might be a possible therapeutic approach in [OA]...

Two vasoactive peptides, endothelin-1 and bradykinin, have been implicated as important players in the pathogenesis of osteoarthritis (OA). The effects of the vasoconstrictor endothelin-1, which include inhibition of collagen and proteoglycan synthesis and induction of synthesis and activation of matrix metalloproteinases 1 and 13, are predominantly mediated via endothelin receptor type A (ETA) expressed in articular chondrocytes, synoviocytes and endothelial cells. Bradykinin, an inflammatory nonapeptide vasodilator, also has a role in OA pain and inflammation mediated mainly via the bradykinin receptor B1 (BKB1). Kaufman and colleagues studied the effects of specific peptide antagonists of ETA and BKB1 on nociception and joint morphology in a surgical model of OA.

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ORIGINAL RESEARCH PAPER

  1. Kaufman, G. N. et al. Nociceptive tolerance is improved by bradykinin receptor B1 antagonism and joint morphology is protected by both endothelin type A and bradykinin receptor B1 antagonism in a surgical model of osteoarthritis. Arthritis Res. Ther. 13, R76 (2011)

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  1. Nick Warde
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Warde, N. Local antagonism of endothelin-1 and bradykinin receptors improves OA pain and joint morphology in rats. Nat Rev Rheumatol 7, 375 (2011). https://doi.org/10.1038/nrrheum.2011.82

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