Components that underlie the heritability of osteoarthritis (OA) are yet to be defined. Contrary to previous results, an analysis of two large genome-wide association study cohorts across a total of 7,393 patients with OA and 5,122 controls has found no association between OA and 48 maternally inherited mitochondrial DNA (mtDNA) variants; accordingly, OA phenotypic subgroups were not associated with mtDNA haplogroups.
ORIGINAL RESEARCH PAPER
Hudson, G. et al. No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls. Ann. Rheum. Dis. doi:10.1136/annrheumdis-2012-201932
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No association between mtDNA variants and osteoarthritis. Nat Rev Rheumatol 8, 633 (2012). https://doi.org/10.1038/nrrheum.2012.174
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DOI: https://doi.org/10.1038/nrrheum.2012.174
