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Fracture repair

Could blockade of Notch signalling promote fracture repair?

Nature Reviews Rheumatology volume 10, page 3 (2014)Cite this article

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Fracture repair relies on contributions from multiple cell types and signalling pathways, details of which require further clarification. A new study by Matthews et al. has, however, added insight into the involvement of periosteal mesenchymal progenitor cells in this process.

Transcriptome analysis also revealed that components of the Notch signalling pathway were substantially downregulated in αSMA+ progenitor cells after fracture, including all Notch receptors and canonical downstream targets. “Notch signalling is an important mediator of communication between neighbouring cells, and controls cell proliferation and differentiation,” explains Kalajzic. “Our findings thus indicate that decreased Notch pathway activity might be necessary for the commitment of the progenitor cells into mature lineages.”

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References

  1. Matthews, B. G. et al. Analysis of αSMA-labeled progenitor cell commitment identifies Notch signaling as an important pathway in fracture healing. J. Bone Miner. Res. 10.1002/jbmr.2140

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  1. David Killock
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Killock, D. Could blockade of Notch signalling promote fracture repair?. Nat Rev Rheumatol 10, 3 (2014). https://doi.org/10.1038/nrrheum.2013.186

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