Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Rheumatoid arthritis

Anti-TNF and anti-IL-17 antibodies—better together!

Nature Reviews Rheumatology volume 10, page 699 (2014)Cite this article

Subjects

Combined blockade of TNF and IL-17 could be a therapeutic approach for patients with rheumatoid arthritis (RA) who fail to respond, or who lose responsiveness, to single-cytokine inhibition, according to a paper now published in Arthritis & Rheumatology.

Georg Schett and colleagues from the University of Erlangen-Nuremberg, Germany, in collaboration with researchers at Roche, investigated the effects of combined inhibition of TNF and IL-17 in inflammatory arthritis. As Schett explains, “We were intrigued by reports on the role of IL-17 in nonresponders and access to cutting-edge protein engineering capabilities has allowed us to test the hypothesis that inhibiting both pathways simultaneously is of benefit.”

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to the full article PDF.

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Fischer, J. A. A. et al. Combined inhibition of TNFα and IL-17 as therapeutic opportunity for treatment in rheumatoid arthritis: development and characterization of a novel bispecific antibody. Arthritis Rheumatol. 10.1002/art.38896

Download references

Authors
  1. Jenny Buckland
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Buckland, J. Anti-TNF and anti-IL-17 antibodies—better together!. Nat Rev Rheumatol 10, 699 (2014). https://doi.org/10.1038/nrrheum.2014.183

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/nrrheum.2014.183

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing