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Osteoarthritis

Circulating miRNAs—early osteoarthritis biomarkers?

Nature Reviews Rheumatology volume 10, page 197 (2014)Cite this article

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“We are the first to identify a specific miRNA signature that predicts the development of severe osteoarthritis of the hip and knee joint,” says Christian Beyer, the corresponding author of a multicentre European collaborative study published in Annals of the Rheumatic Diseases.

Current methods of detecting osteoarthritis (OA), such as MRI, are not sensitive enough to detect the very early stages of disease, limiting their usefulness for early intervention. Beyer's data identify the microRNA (miRNA) let-7e as a potential biomarker for early detection of severe OA. He says of his new data, “the lower the let-7e levels, the higher the likelihood of more than one joint replacement surgery.”

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References

  1. Beyer, C. et al. Signature of circulating microRNAs in osteoarthritis. Ann. Rheum. Dis. 10.1136/annrheumdis-2013-204698

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  1. Nicholas J. Bernard
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Bernard, N. Circulating miRNAs—early osteoarthritis biomarkers?. Nat Rev Rheumatol 10, 197 (2014). https://doi.org/10.1038/nrrheum.2014.25

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