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Autoinflammation

Anakinra effective for resistant FMF in RCT

Nature Reviews Rheumatology volume 13, page 2 (2017)Cite this article

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The results of a randomized placebo-controlled trial show that the IL-1 receptor antagonist anakinra is safe and effective for the treatment of colchicine-resistant familial Mediterranean fever (FMF). The study enroled 25 adults receiving treatment with 1.5–3 mg colchicine per day, who were then randomly assigned to receive anakinra or placebo for 4 months. Among those treated with anakinra, the mean number of FMF attacks per patient per month was 1.7±1.7, compared with 3.5±1.9 among those who received placebo (P = 0.037). Six patients in the anakinra group had less than one FMF attack per month whereas no patients in the placebo group achieved this outcome (P = 0.005). The rate of adverse events was similar in both groups, and anakinra treatment also had a beneficial effect on quality of life.

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References

  1. Ben-Zvi, I. et al. Anakinra for colchicine resistant familial Mediterranean fever — a randomized, double blind, placebo-controlled trial. Arthritis Rheumatol. http://dx.doi.org/10.1002/art.39995 (2016)

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  1. Sarah Onuora
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Onuora, S. Anakinra effective for resistant FMF in RCT. Nat Rev Rheumatol 13, 2 (2017). https://doi.org/10.1038/nrrheum.2016.205

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