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Systemic lupus erythematosus

Effects of disease activity on pregnancy outcomes

Nature Reviews Rheumatology volume 14, page 4 (2018)Cite this article

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Comparison of data on births in women with systemic lupus erythematosus (SLE; n = 180) and in the general population in Norway (n = 498,849) has revealed links between disease activity and pregnancy outcomes. Patients with SLE had an increased risk of low birth weight in neonates (P < 0.001) and preterm birth (P = 0.003) compared with population controls, effects that were more pronounced in the setting of active disease. Patients with active disease also had an increased risk of pre-eclampsia compared with the general population or patients with inactive disease (P < 0.001 and P = 0.052, respectively).

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References

  1. Götestam Skorpen, C. et al. Influence of disease activity and medications on offspring birth weight, pre-eclampsia and preterm birth in systemic lupus erythematosus: a population-based study. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2017-211641 (2017)

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  1. Joanna Collison
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Collison, J. Effects of disease activity on pregnancy outcomes. Nat Rev Rheumatol 14, 4 (2018). https://doi.org/10.1038/nrrheum.2017.195

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