Two recent crystal structures show channel-forming bacterial toxins as soluble monomers (colicin la) or transmembrane pores (α-haemolysin). Together with other data, these structures imply that toxin activity requires dramatic conformational changes.
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Hughson, F. Penetrating insights into pore formation. Nat Struct Mol Biol 4, 89–92 (1997). https://doi.org/10.1038/nsb0297-89
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DOI: https://doi.org/10.1038/nsb0297-89
