The crystal structure of the catalytic domain of adenylyl cyclase in complex with its activator Gsα suggests a surprising allosteric mechanism of activation by formation of a new catalytic site at the interface between conserved dimers of the soluble adenylyl cyclase domains.
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Skiba, N., Hamm, H. How Gsα activates adenylyl cyclase. Nat Struct Mol Biol 5, 88–92 (1998). https://doi.org/10.1038/nsb0298-88
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DOI: https://doi.org/10.1038/nsb0298-88
