The solution structure of HIV-1 Nef and mapping of its binding surface for the SH3 domain of a protein tyrosine kinase illustrates how the primate lentiviruses have tapped into host cell activation pathways.
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Stevenson, M. Pathway to understanding AIDS. Nat Struct Mol Biol 3, 303–306 (1996). https://doi.org/10.1038/nsb0496-303
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DOI: https://doi.org/10.1038/nsb0496-303
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