The determination of the three-dimensional structure of the Escherichia coli Lac represser by X-ray crystallography reveals much of the mechanism of action of this historically important molecule.
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Miller, J. Structure of a paradigm. Nat Struct Mol Biol 3, 310–312 (1996). https://doi.org/10.1038/nsb0496-310
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DOI: https://doi.org/10.1038/nsb0496-310