The molecular basis of redox sensitivity in proteins is not well understood. Here we consider a continuum of NO- and O2-related modifications of cysteine residues that constitute biological signaling events on the one hand and hallmarks of nitrosative and oxidative stresses on the other.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Nature Chemical Biology Open Access 20 October 2022
-
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases
Apoptosis Open Access 23 February 2010
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Becker, K., Savvides, S.N., Keese, M., Schirmer, R.H. & Karplus, P.A. Nature Struct. Biol. 5, 267–271 (1998).
Stamler, J.S., Toone, E.J., Lipton, S.A. & Sucher, N.J. Neuron 18, 691–696 (1997).
Vanin, A.F., Malenkova, I.V. & Serezhenkov, V.A. NITRIC OXIDE: Biology and Chemistry 1, 191–203 (1997).
Feelisch, M. & Stamler, J.S. Donors of nitrogen oxides in: Methods in Nitric Oxide Research (eds Feelisch, M. & Stamler, J.S.) 71–115 (John Wiley & Sons, Ltd., Chichester, England, 1996).
Boese, M., Mordvintcev, P.I., Vanin, A.F., Busse, R. & Mülsch, A. J. Biol. Chem. 270, 29244–29249 (1995).
Arnelle, D.R. & Stamler, J.S. Arch. Biochem. Biophys. 318, 279–285 (1995).
Hausladen, A., Privalle, C.T., Keng, T., DeAngelo, J. & Stamler, J.S. Cell, 86, 719–729 (1996).
Gaston, B. et al. Proc. Natl. Acad. Sci. USA 90, 10957–10961 (1993).
Wink, D.A. et al. Chem. Res. Toxicol. 7, 519–525 (1994).
Lewis, R.S., Tamir, S., Tannenbaum, S.R. & Deen, W.M. J. Biol. Chem. 270, 29350–29355 (1995).
Oae, S. & Shinhama, K. Organic Preparations and Procedures 15, 165–198 (1983).
Simon, D.I. et al. Proc. Natl. Acad. Sci. USA 93, 4736–4741 (1996).
Boese, M., Keese, M.A., Becker, K., Busse, R. & Mülsch, A. J. Biol. Chem. 272, 21767–21773 (1997).
Allison, W.S. Accounts Chem. Res. 9, 293–299 (1976).
Claiborne, A., Miller, H., Parsonage, D. & Ross, R.P. FASEBJ. 7, 1483–1490 (1993).
Yeh, J.I., Claiborne, A., Hol, W.G.J. Biochemistry 35, 9951–9957 (1996).
Stamler, J.S. Cell 78, 931–936 (1994).
Stamler, J.S. et al.Science 276, 2034–2037 (1997).
Morris, S.L. & Hansen, J.N. et al. J. Bacteriol. 148, 465–471 (1981).
Field, L., Dilts, R.V., Ravichandran, R., Lenhert, P.G. & Carnahan, G.E. J.C.S. Chem. Comm. 248–249 (1978).
Xu, L., Eu, J.P., Meissner, G. & Stamler, J.S. Science 279, 234–237 (1998).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Stamler, J., Hausladen, A. Oxidative modifications in nitrosative stress. Nat Struct Mol Biol 5, 247–249 (1998). https://doi.org/10.1038/nsb0498-247
Issue date:
DOI: https://doi.org/10.1038/nsb0498-247
This article is cited by
-
Nitric oxide-driven modifications of lipoic arm inhibit α-ketoacid dehydrogenases
Nature Chemical Biology (2023)
-
Fish Oil Supplementation Decreases Oxidative Stress but Does Not Affect Platelet‐Activating Factor Bioactivity in Lungs of Asthmatic Rats
Lipids (2014)
-
Inorganic Phosphate Induces Mammalian Growth Plate Chondrocyte Apoptosis in a Mitochondrial Pathway Involving Nitric Oxide and JNK MAP Kinase
Calcified Tissue International (2011)
-
Redox regulation of mitochondrial fission, protein misfolding, synaptic damage, and neuronal cell death: potential implications for Alzheimer’s and Parkinson’s diseases
Apoptosis (2010)
-
S-nitrosylation of PTEN Invovled in Ischemic Brain Injury in Rat Hippocampal CA1 Region
Neurochemical Research (2009)
