Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Ankyrin(g) ETS domains to DNA

The crystal structure of the heterodimeric transcriptional regulator GABPα/β bound to DNA reveals extensive protein–protein interactions between an ETS domain and ankyrin repeats that may influence DNA binding affinity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Karim, F. et al. Genes Dev. 4, 1451–1453 (1990).

    Article  CAS  Google Scholar 

  2. Kodandapani, R. et al. Nature 380, 456–460 (1996).

    Article  CAS  Google Scholar 

  3. Liang, H. et al. Nature Struct. Biol. 1, 871–875 (1994).

    Article  CAS  Google Scholar 

  4. Donaldson, L.W., Petersen, J.M., Graves, B.J. & McIntosh, L.P. EMBO J. 15, 125–134 (1996).

    Article  CAS  Google Scholar 

  5. Werner, M.H. et al. Cell 83, 761–771 (1995) [published erratum Cell 87, 355 (1996)].

    Article  CAS  Google Scholar 

  6. Klemsz, M.J., McKercher, S.R., Celada. A., Van Beveren, C. & Maki, R.A. Cell 61, 113–124 (1990).

    Article  CAS  Google Scholar 

  7. Watson, D.K. et al. Proc. Natl. Acad. Sci. USA 82, 7294–7298 (1985).

    Article  CAS  Google Scholar 

  8. Reddy, E.S. & Rao, V.N. Oncogene Res. 3, 239–246 (1988).

    CAS  PubMed  Google Scholar 

  9. Reddy, E.S., Rao, V.N. & Papas, T.S. Proc. Natl. Acad. Sci. USA 84, 6131–6135 (1987).

    Article  CAS  Google Scholar 

  10. Rao, V.N. et al., Science 244, 66–70 (1989).

    Article  CAS  Google Scholar 

  11. Petersen, J.M. et al. Science 269, 1866–1869 (1995).

    Article  CAS  Google Scholar 

  12. Graves, B.J. & Petersen, J.M. Adv. Cancer Res., (eds G. van de Woude, G. Klein) (Academic Press, San Diego, 1998).

    Google Scholar 

  13. Batchelor, A.H., Piper, D.E., de la Brousse, F.C., McKnight, S.L. & Wolberger, C. Science, 279, 1037–1041 (1998).

    Article  CAS  Google Scholar 

  14. Pio, F. et al. J. Biol. Chem. 271, 23329–23337 (1996).

    Article  CAS  Google Scholar 

  15. Shore, P. et al. Mol. Cell. Biol. 16, 3338–3349.

  16. Nikolajczyk, B.S., Nelsen, B. & Sen, R. Mol. Cell. Biol. 16, 4544–4554 (1996).

    Article  CAS  Google Scholar 

  17. Strauss, J.K. & Maher, L.J. III Science 266, 1829–1834 (1994).

    Article  CAS  Google Scholar 

  18. Strauss-Soukop, J.K. and Maher, L.J. III, J. Biol. Chem. 272, 31570–31575.

  19. LaMarco, K., Thomspon, C.C., Byers, B.P., Walton, E.M. & McKnight, S.L. Science 253, 789–792 (1991).

    Article  CAS  Google Scholar 

  20. Watanabe, H. et al. Mol. Cell. Biol. 13, 1385–1391 (1993).

    Article  CAS  Google Scholar 

  21. Thompson, C.C., Brown, T.A. & McKnight, S.L. Science 253, 762–765 (1991).

    Article  CAS  Google Scholar 

  22. Gorina, S. & Pavletich, N.P. Science 274, 1001–1005 (1996).

    Article  CAS  Google Scholar 

  23. Luh, F.Y. et al. Nature 389, 999–1003 (1997).

    Article  CAS  Google Scholar 

  24. Venkataramani, R., Swaminathan, K. and Marmorstein R. Nature Struct. Biol. 5, 74–81 (1998).

    Article  CAS  Google Scholar 

  25. Shaw, P.E., Schroter, H. & Nordheim, A. Cell 56, 563–572 (1989).

    Article  CAS  Google Scholar 

  26. Pongubala, J.M.R. et al. Mol. Cell. Biol. 12, 368–378 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kathryn R. Ely.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ely, K., Kodandapani, R. Ankyrin(g) ETS domains to DNA. Nat Struct Mol Biol 5, 255–259 (1998). https://doi.org/10.1038/nsb0498-255

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/nsb0498-255

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing