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The thermosome: chaperonin with a built-in lid

Nature Structural Biology volume 5, pages 333–336 (1998)Cite this article

Recent crystal structures of the Thermoplasma acidophilum thermosome and its isolated apical domain suggest that an integral extension of the apical domain encloses the folding-active chaperonin central cavity.

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References

  1. Bukau, B. & Horwich, A.L. Cell 92, 351–366 (1998).

    Article  CAS  Google Scholar 

  2. Ranson, N.A., White, H.M. & Saibil, H.R. Biochem. J. in the press (1998).

  3. Hartl, F.U. Nature 381, 571–580 (1996).

    Article  CAS  Google Scholar 

  4. Willison, K. & Horwich, A.L., The chaperonins (ed. Ellis, R.I.) 107–136 (Academic Press, New York; 1996).

    Book  Google Scholar 

  5. Klumpp, M., Baumeister, W. & Essen, L.O. Cell 91, 263–270 (1997).

    Article  CAS  Google Scholar 

  6. Ditzel, L. et al. Cell 93, 125–138 (1998).

    Article  CAS  Google Scholar 

  7. Ranson, N.A., Dunster, N.J., Burston, S.G. & Clarke, A.R. J. Mol. Biol. 250, 581–586 (1995).

    Article  CAS  Google Scholar 

  8. Zahn, R., Perrett, S.G. & Fersht, A.R. Science 271, 642–645 (1996).

    Article  CAS  Google Scholar 

  9. Walter, S., Lorimer, G.H. & Schmid, F.X. Proc. Natl. Acad Sci. USA 93, 9425–9430 (1996).

    Article  CAS  Google Scholar 

  10. Todd, M.J., Lorimer, G.H. & Thirumalai, D. Proc. Natl. Acad. Sci. USA 93, 4030–4035 (1997).

    Article  Google Scholar 

  11. Roseman, A.M., Chen, S., White, H., Braig, K. & Saibil, H.R. Cell 87, 241–251 (1996).

    Article  CAS  Google Scholar 

  12. Xu, Z., Horwich, A. L. & Sigler, P. B. Nature 388, 741–750 (1997).

    Article  CAS  Google Scholar 

  13. Rye, H. S. et al. Nature 388, 792–798 (1997).

    Article  CAS  Google Scholar 

  14. Phipps, B. M., Hoffman, A., Stetter, K. O. & Baumeister, W. EMBO J. 10, 1711–1722 (1991).

    Article  CAS  Google Scholar 

  15. Kim, S., Willison, K.R. & Horwich, A.L. Trends Biochem. Sci. 19, 542–548 (1994).

    Article  Google Scholar 

  16. Braig, K. et al. Nature 371, 578–586 (1994).

    Article  CAS  Google Scholar 

  17. Fenton, W. A., Kashi, Y., Furtak, K. & Horwich, A. L. Nature 371, 614–619 (1994).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA

    Arthur L. Horwich

  2. Department of Crystallography, Birbeck College, London, WC1E 7HX, UK

    Helen R. Saibil

Authors
  1. Arthur L. Horwich
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  2. Helen R. Saibil
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Horwich, A., Saibil, H. The thermosome: chaperonin with a built-in lid. Nat Struct Mol Biol 5, 333–336 (1998). https://doi.org/10.1038/nsb0598-333

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