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Methyl magic and HAT tricks

Nature Structural Biology volume 9, pages 888–891 (2002)Cite this article

The structures of four lysine methyltransferases give us the first glimpse of the molecular architecture responsible for histone/protein lysine methylation, whereas a recent study of the Esa1 histone acetyltransferase suggests that lysine acetyltransferases still have surprises in store.

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Figure 1: Architecture of SET domain lysine methyltransferases.
Figure 2: Comparative anatomy of the active site of the Esa1 and Gcn5-like histone acetyltransferases.

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Authors and Affiliations

  1. the Division of Biological Sciences, Section of Molecular Biology, University of California San Diego, La Jolla, 92093-0347, California, USA

    Robert N. Dutnall

  2. the Department of Biochemistry and Molecular Biology, Oregon Health & Science University, Portland, 97201, Oregon, USA

    John M. Denu

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  1. Robert N. Dutnall
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  2. John M. Denu
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Dutnall, R., Denu, J. Methyl magic and HAT tricks. Nat Struct Mol Biol 9, 888–891 (2002). https://doi.org/10.1038/nsb1202-888

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