A comparison of the three dimensional structures of neurotoxic peptides reveals distinct electrostatic topographies that help define surfaces important for binding and kinetic properties.
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References
Olivera, B.M., Miljanich, G.P., Ramachandran, J. & Adams, M.E. Ann. Rev. Biochem. 63, 823–867 (1994).
Narasimhan, L., Singh, J., Humblet, C., Guruprasada, K. & Blundell, T. Nature struct. Biol. 1, 781–788 (1994).
Adams, M.E., Mintz, I.M., Reily, M.D., Thanabal, V. & Bean, B.P. Mol. Pharmacol. 44, 681–688 (1993).
Mintz, I.M., Adams, M.E. & Bean, B.P. Neuron 9, 85–95 (1992).
Reily, M.D., Thanabal, V. & Adams, M.E. J. biomol. NMR, in the press.
Yu, H., Rosen, M.K., Saccomano, N.A., Phillips, D., Volkmann, R.A. & Schreiber, S.L. Biochemistry 32, 13123–13129 (1993).
Wagner, G. et al. J. molec. Biol. 196, 611–639 (1987).
Hyberts, S.G., Goldberg, M.S., Havel, T.F. & Wagner G. Prot. Sci. 7, 736–751 (1992).
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Reily, M., Holub, K., Gray, W. et al. Structure-activity relationships for P-type calcium channel-selective ω-agatoxins. Nat Struct Mol Biol 1, 853–856 (1994). https://doi.org/10.1038/nsb1294-853
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DOI: https://doi.org/10.1038/nsb1294-853
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