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A molecular dipstick?

Nature Structural Biology volume 4, pages 966–968 (1997)Cite this article

The first mammalian lipoxygenase crystal structure reveals the surprising presence of an N-terminal β-barrel domain that is highly similar to the C-terminal domain of pancreatic Upases. The non-haem iron-containing catalytic domain is a compact version of the soybean lipoxygenase-1 major domain.

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References

  1. Funk, C.D. Biochim. Biophys. Acta 1304, 65–84 (1996).

    Article  Google Scholar 

  2. Samuelsson, B., Dahlén, S.E., Lindgren, J.-Å., Rouzer, C.A. & Serhan, C.N. Science 237, 1171–1175 (1987).

    Article  CAS  Google Scholar 

  3. Rapoport, S.M. et al., Eur. J. Biochem. 96, 545–561 (1979).

    Article  CAS  Google Scholar 

  4. Ostareck, D.H. et al. Cell 89, 597–606 (1997).

    Article  CAS  Google Scholar 

  5. Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C. & Witztum, J.L. N. Engl. J. Med. 320, 915–924 (1989).

    Article  CAS  Google Scholar 

  6. Harats, D., Mulkins, M.A. and Sigal, E. Trends Cardiovasc. Med. 5, 29–36 (1995).

    Article  CAS  Google Scholar 

  7. Boyington, J.C., Gaffney, B.J. & Amzel, L.M. Science 260, 1482–1486 (1993).

    Article  CAS  Google Scholar 

  8. Minor, W. et al. Biochemistry 35, 10687–10701 (1996).

    Article  CAS  Google Scholar 

  9. Kühn, H., Sprecher, H. & Brash, A.R. J. Biol. Chem. 265, 16300–16305 (1990).

    PubMed  Google Scholar 

  10. Carroll, R.T. et al. Lipids 28, 241–244 (1993).

    Article  CAS  Google Scholar 

  11. Picot, D., Loll, P.J. & Garavito, M. Nature 367, 243–249 (1994).

    Article  CAS  Google Scholar 

  12. Luong, C. et al. Nature Struct. Biol. 3, 927–933 (1996).

    Article  CAS  Google Scholar 

  13. Gan, Q.-F., Browner, M.F., Sloane, D.L. & Sigal, E. J. Biol. Chem. 271, 25412–25418 (1996).

    Article  CAS  Google Scholar 

  14. Gardner, H.W. Biochim. Biophy. Acta 1001, 274–281 (1989).

    Article  CAS  Google Scholar 

  15. Brash, A.R., Boeglin, W.E., Chang, M.S. & Shieh, B.-H. J. Biol. Chem. 271, 20949–20957 (1996).

    Article  CAS  Google Scholar 

  16. Borngräber, S., Kuban, R.-J., Anton, M. & Kuhn, H. J. Mol. Biol. 264, 1145–1153 (1996).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. the Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Colin D. Funk & Patrick J. Loll

  2. also at the Center for Experimental Therapeutics,

    Colin D. Funk

Authors
  1. Colin D. Funk
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  2. Patrick J. Loll
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Funk, C., Loll, P. A molecular dipstick?. Nat Struct Mol Biol 4, 966–968 (1997). https://doi.org/10.1038/nsb1297-966

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