Figure 1: Overview of statistical approach.
From: Analysis of microRNA-target interactions across diverse cancer types
Statistical method used to evaluate recurrence of miRNA-mRNA expression association across cancer types. In individual cancer types, pairwise miRNA-mRNA relationships are evaluated using a multivariate linear model, which also factors in variation (noise) in mRNA expression induced by changes in DNA copy number and promoter methylation at the mRNA gene locus. Associations are rank transformed in individual cancer types, and the method subsequently evaluates the null hypothesis that no association exists between the miRNA-mRNA pair in all cancer types.
