Figure 2: Concordance with predicted miRNA-target interactions.
From: Analysis of microRNA-target interactions across diverse cancer types
(a) Enrichment of predicted miRNA-target interactions as a function of miRNA-mRNA expression association in the ten cancer types (using 100 equally sized bins; cancer types are color coded as in Fig. 1). (b) Enrichment for predicted target interactions in the percentile of miRNA-mRNA pairs with strongest negative association, evaluated using different thresholds for miRNA target prediction methods: miRanda-miRSVR score (−0.15 versus −1.2), TargetScan context score (−0.1 versus −0.45) and presence of heptamer in mRNA 5′ UTR, coding sequence and 3′ UTR. Enrichment was evaluated using Fisher's exact test. (c) The top ten inferred recurring negative miRNA-mRNA associations. Left, inferred association rank (negative to positive) in each cancer type. Predicted target interactions with bars corresponding to (absolute) scores of three target prediction methods: miRanda-miRSVR, TargetScan context score and TargetScan conservation. (d) Results are available at http://cancerminer.org.
